|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of rs2853669 with telomerase reverse transcriptase (TERT) mRNA level and relative telomere length (RTL) was analysed using resected tumour samples from 250 NSCLC patients.
|
31446212 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The univariate analysis has revealed that carriers of CC SNP (rs2853669) have had the shortest RTL in the T2DM group.
|
29938393 |
2018 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Possible association of the TERT promoter polymorphisms rs2735940, rs7712562 and rs2853669 with diabetes mellitus in obese elderly Polish population: results from the national PolSenior study.
|
29938393 |
2018 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggest that the TERT rs2853669 polymorphism is associated with a significantly increased risk of cancer, particularly lung cancer, in Asian populations.
|
29534075 |
2018 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggest that the TERT rs2853669 polymorphism is associated with a significantly increased risk of cancer, particularly lung cancer, in Asian populations.
|
29534075 |
2018 |
|
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggest that the TERT rs2853669 polymorphism is associated with a significantly increased risk of cancer, particularly lung cancer, in Asian populations.
|
29534075 |
2018 |
|
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggest that the TERT rs2853669 polymorphism is associated with a significantly increased risk of cancer, particularly lung cancer, in Asian populations.
|
29534075 |
2018 |
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggest that the TERT rs2853669 polymorphism is associated with a significantly increased risk of cancer, particularly lung cancer, in Asian populations.
|
29534075 |
2018 |
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
In this study, it was found that there was no statistical difference between hTERT rs2736109 G>A, rs2735940 T>C, rs2853669 A>G, rs2736098 G>A, and rs2736100 T>G polymorphisms that can be associated with risk of BC.
|
29506639 |
2018 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this study, it was found that there was no statistical difference between hTERT rs2736109 G>A, rs2735940 T>C, rs2853669 A>G, rs2736098 G>A, and rs2736100 T>G polymorphisms that can be associated with risk of BC.
|
29506639 |
2018 |
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation
|
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Collectively, our functional studies of the <i>TERT</i>-<i>CLPTM1L</i> breast cancer susceptibility locus describe rs2853669 as a functional variant of this association signal among three other potentially causal variants and demonstrate the versatile mechanisms by which <i>TERT</i> promoter variants may affect breast cancer risk.
|
28978027 |
2017 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, our functional studies of the <i>TERT</i>-<i>CLPTM1L</i> breast cancer susceptibility locus describe rs2853669 as a functional variant of this association signal among three other potentially causal variants and demonstrate the versatile mechanisms by which <i>TERT</i> promoter variants may affect breast cancer risk.
|
28978027 |
2017 |
|
Glioblastoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Pre-operative MRIs of 64/67 genetically confirmed primary GBM patients (51/67 TERT-mutated with rs2853669 polymorphism) were analyzed according to Visually AcceSAble Rembrandt Images (VASARI) ( https://wiki.cancerimagingarchive.net/display/Public/VASARI+Research+Project ) imaging criteria by three radiological raters.
|
28894890 |
2017 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, we identified a modifying effect of rs2853669 on <i>TERTp</i> mutations in that, among cancer patients with <i>TERTp</i> mutations, only those carrying the TT genotype had a poor survival (Hazard ratio = 1.56, 95% confidence interval = 1.06-2.28); subgroup analyses by cancer type also supported these results.
|
28881610 |
2017 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
Subsequent analyses also did not reveal any association between rs2853669 and overall cancer prognosis.
|
28881610 |
2017 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that G allele of rs2736100 and G allele of rs2853669 in TERT gene, interaction between rs2736100 and smoking, and haplotype containing the rs2736100- G and rs2736109- A alleles were all associated with increased GC risk.
|
28423629 |
2017 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that G allele of rs2736100 and G allele of rs2853669 in TERT gene, interaction between rs2736100 and smoking, and haplotype containing the rs2736100- G and rs2736109- A alleles were all associated with increased GC risk.
|
28423629 |
2017 |
|
Ependymoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We determined telomerase enzymatic activity, hTERT mRNA expression, promoter methylation, and the rs2853669 single nucleotide polymorphism located in the hTERT promoter in a well-characterized cohort of pediatric intracranial ependymomas.
|
28371821 |
2017 |
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
We also found rs2853669 and rs2736098 polymorphisms were significantly associated with breast cancer risk (OR = 0.76; 95% CI: 0.63-0.90; P = 0.002 and OR = 0.79; 95% CI: 0.72-0.87; P < 0.00001), respectively.
|
27461695 |
2017 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
We also found rs2853669 and rs2736098 polymorphisms were significantly associated with breast cancer risk (OR = 0.76; 95% CI: 0.63-0.90; P = 0.002 and OR = 0.79; 95% CI: 0.72-0.87; P < 0.00001), respectively.
|
27461695 |
2017 |
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
It was observed that hTERT rs2736098 was associated with breast cancer risk (odds ratio [OR] = 1.88; p = 0.034), while rs2736100 and rs2853669 did not significantly differ between the groups.
|
27336831 |
2016 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
It was observed that hTERT rs2736098 was associated with breast cancer risk (odds ratio [OR] = 1.88; p = 0.034), while rs2736100 and rs2853669 did not significantly differ between the groups.
|
27336831 |
2016 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Because this is the first study regarding the hTERT rs2736109 G>A, rs2735940 T>C, rs2853669 A>G and rs2736100 T>G polymorphisms and the risk of GC susceptibility in the literature, further independent studies are needed to verify our results in a larger sample sizes, as well as in patients of different populations.
|
27016301 |
2016 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
Because this is the first study regarding the hTERT rs2736109 G>A, rs2735940 T>C, rs2853669 A>G and rs2736100 T>G polymorphisms and the risk of GC susceptibility in the literature, further independent studies are needed to verify our results in a larger sample sizes, as well as in patients of different populations.
|
27016301 |
2016 |